rss_2.0Journal of Translational Internal Medicine FeedSciendo RSS Feed for Journal of Translational Internal Medicinehttps://sciendo.com/journal/JTIMhttps://www.sciendo.comJournal of Translational Internal Medicine 's Coverhttps://sciendo-parsed-data-feed.s3.eu-central-1.amazonaws.com/606af9253999800867736d72/cover-image.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20220522T080302Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=AKIA6AP2G7AKDOZOEZ7H%2F20220522%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=200436871ca787769172a41dd05ffe6a986d9b1b7653669e22692d21e1a42237200300Protective role of autophagy in triptolide-induced apoptosis of TM3 Leydig cellshttps://sciendo.com/article/10.2478/jtim-2021-0051<abstract> <title style='display:none'>Abstract</title> <sec id="j_jtim-2021-0051_s_006"> <title style='display:none'>Background and Objectives</title> <p>Triptolide (TP) is known to impair testicular development and spermatogenesis in mammals, but the mechanism of the side effects still needs to be investigated. The aim of the research is to confirm whether TP can cause autophagy in TM3 Leydig cells and the potential molecular pathway in vitro.</p> </sec> <sec id="j_jtim-2021-0051_s_007"> <title style='display:none'>Methods</title> <p>TM3 Leydig cells are used to investigate the molecular pathway through Western blot, detection of apoptosis, transmission electron microscopy for autophagosomes and so on.</p> </sec> <sec id="j_jtim-2021-0051_s_008"> <title style='display:none'>Results</title> <p>The data show that TP treatment resulted in the decreasing of the viability of TM3 cells due to the increased apoptosis. Treated with TP, the formation of autophagosomes, the decrease in P62, and the increase in the conversion of LC3-I to LC3-II suggested the induction of autophagy. The induction of autophagy has accompanied the activation of the mTOR/P70S6K signal pathway. The viability of the TM3 cells was further inhibited when they were co-treated with autophagy inhibitor, chloroquine (CQ).</p> </sec> <sec id="j_jtim-2021-0051_s_009"> <title style='display:none'>Conclusion</title> <p>All these data suggest that autophagy plays a very important role in antagonizing TM3 cell apoptosis during the TP exposure.</p> </sec> </abstract>ARTICLE2022-05-05T00:00:00.000+00:00Inhaled antibiotics and airway bacterial decolonization for patients with chronic obstructive pulmonary disease: The rationale and futurehttps://sciendo.com/article/10.2478/jtim-2022-0005ARTICLE2022-05-04T00:00:00.000+00:00Hyperoxaluria: An early diagnosis will allow a timely combined renal and liver transplantations to avoid irreversible damages to all other organshttps://sciendo.com/article/10.2478/jtim-2020-0099<abstract> <title style='display:none'>ABSTRACT</title> <p>A 4-month-old patient was admitted to the emergency room for vomiting, weight gain, food refusal and hypertension. Blood gases showed a metabolic acidosis with increased anion gap. Laboratory finding revealed severe renal failure (creatinine 8 mg/dL). Renal ultrasound showed an important hyperechogenicity of the parenchyma with loss of cortico-medullar differentiation suggesting a nephronophytosis. Genetic testing was negative. Urine oxalate levels were increased to 140 μmol/L. New genetic tests were positive for type I hyperoxaluria. The authors discuss the management of hyperoxaluria.</p> </abstract>ARTICLE2021-12-31T00:00:00.000+00:00Single-nucleotide polymorphisms in medical nutritional weight loss: Challenges and future directionshttps://sciendo.com/article/10.2478/jtim-2022-0002ARTICLE2022-04-09T00:00:00.000+00:00Prevalence of left atrial septal pouch among patients with embolic stroke of undetermined source or stroke of known etiology: A retrospective studyhttps://sciendo.com/article/10.2478/jtim-2022-0032<abstract> <title style='display:none'>Abstract</title> <sec id="j_jtim-2022-0032_s_007"><title style='display:none'>Background and objectives</title> <p>Cryptogenic strokes can be defined by the criteria established for an embolic stroke of undetermined source (ESUS). Some embolic events might be caused by a left atrial septal pouch (LASP), due to the potential of thrombus formation. In this study we aimed to determine if LASP is a risk factor for ESUS when compared to a population of strokes of known origin, the LASP screening rate in our institution and if LASP dimensions influences the risk of ESUS.</p></sec> <sec id="j_jtim-2022-0032_s_008"><title style='display:none'>Methods</title> <p>We retrospectively analyzed transesophageal echocardiograms (TEEs) in a large cohort of patients that had experienced ischemic strokes. Two authors performed blinded, independent searches for LASPs by reviewing 1152 TEEs from patients that had experienced a stroke or transient ischemic attack. We excluded 26 TEEs, due to incorrect imaging. Next, we reviewed patient medical files.</p></sec> <sec id="j_jtim-2022-0032_s_009"><title style='display:none'>Results</title> <p>Among the 1126 included patients, 148 had an ESUS (ESUS+ group) and 978 had strokes of known origin (ESUS– group). A LASP was present in 176 patients, including 32 patients (21.6% of LASPs) in the ESUS+ group and 144 patients (14.7% of LASPs) in the ESUS– group. In multivariate analysis, LASP was independently associated with ESUS (<italic>P</italic> = 0,019). 61.9% of LASPs that we found were not mentioned in reports from the original TEE operators.</p></sec> <sec id="j_jtim-2022-0032_s_010"><title style='display:none'>Conclusion</title> <p>This study demonstrated that LASPs were more prevalent in patients with ESUS than in patients with strokes of known origin. Our results gave rise to the question of whether anticoagulation would be appropriate for some patients with ESUS. New large-scale, prospective studies should be conducted to address this issue. Additionally, considering the low rate of LASP descriptions, we concluded that the awareness of operators should be raised to improve their success in identifying LASPs.</p></sec> </abstract>ARTICLE2022-04-09T00:00:00.000+00:00Immune checkpoint inhibitor-related endocrinopathieshttps://sciendo.com/article/10.2478/jtim-2022-0009ARTICLE2022-04-02T00:00:00.000+00:00Predicting survival for hepatic arterial infusion chemotherapy of unresectable colorectal liver metastases: Radiomics analysis of pretreatment computed tomographyhttps://sciendo.com/article/10.2478/jtim-2022-0004<abstract> <title style='display:none'>Abstract</title> <sec id="j_jtim-2022-0004_s_005"> <title style='display:none'>Objective</title> <p>Hepatic arterial infusion chemotherapy (HAIC) is an effective treatment for advanced unresectable colorectal cancer liver metastases (CRLM). This study was conducted to predict the efficacy of HAIC in patients with unresectable CRLM by radiomics methods based on pretreatment computed tomography (CT) examinations and clinical data.</p> </sec> <sec id="j_jtim-2022-0004_s_006"> <title style='display:none'>Materials and Methods</title> <p>A total of 63 patients were included in this study (41 in the training group and 22 in the validation group). All these patients underwent CT examination before HAIC. During the follow-up period, CT scans and laboratory examinations were performed regularly. Eighty-five radiological features were extracted from the regions of interest (ROIs) of CT images using the PyRadiomics program. The <italic>t</italic>-test and correlation were applied to select features. These features were analyzed using LASSO-Cox regression, and a linear model was developed to predict overall survival (OS).</p></sec> <sec id="j_jtim-2022-0004_s_007"> <title style='display:none'>Results</title> <p>After reducing features by <italic>t</italic>-test and correlation test, seven features remained. After LASSO-Cox cross-validation, four features remained at λ = 0.232. They were gray level co-occurrence matrix (GLCM), gray level run length matrix (GLRLM), neighborhood gray tone difference matrix (NGTDM), and the location of the primary tumor. The C-index was 0.758 in the training group and 0.743 in the test group. Nomograms predicting 1-, 2-, and 3-year survival were established.</p></sec> <sec id="j_jtim-2022-0004_s_008"> <title style='display:none'>Conclusion</title> <p>Our study demonstrates that a radiomics approach based on pretreatment CT texture analysis has the ability to predict early the outcome of HAIC in patients with advanced unresectable colorectal cancer with a high degree of accuracy and feasibility.</p></sec> </abstract>ARTICLE2022-04-02T00:00:00.000+00:00Hyperchloremic metabolic acidosis post hysteroscopy: A place for balanced solutions?https://sciendo.com/article/10.2478/jtim-2022-0010ARTICLE2022-04-02T00:00:00.000+00:00Current development of a nonpharmacological intervention approach for mild cognitive impairment patients and a clinical trial in Chinahttps://sciendo.com/article/10.2478/jtim-2022-0007ARTICLE2022-04-02T00:00:00.000+00:00Prevalence of left atrial septal pouch among patients with embolic stroke of undetermined source or stroke of known etiology: A retrospective studyhttps://sciendo.com/article/10.2478/jtim-2021-0055<abstract> <title style='display:none'>Abstract</title> <sec id="j_jtim-2021-0055_s_007"> <title style='display:none'>Background and objectives</title> <p>Cryptogenic strokes can be defined by the criteria established for an embolic stroke of undetermined source (ESUS). Some embolic events might be caused by a left atrial septal pouch (LASP), due to the potential of thrombus formation. In this study we aimed to determine if LASP is a risk factor for ESUS when compared to a population of strokes of known origin, the LASP screening rate in our institution and if LASP dimensions influences the risk of ESUS.</p> </sec> <sec id="j_jtim-2021-0055_s_008"> <title style='display:none'>Methods</title> <p>We retrospectively analyzed transesophageal echocardiograms (TEEs) in a large cohort of patients that had experienced ischemic strokes. Two authors performed blinded, independent searches for LASPs by reviewing 1152 TEEs from patients that had experienced a stroke or transient ischemic attack. We excluded 26 TEEs, due to incorrect imaging. Next, we reviewed patient medical files.</p></sec> <sec id="j_jtim-2021-0055_s_009"> <title style='display:none'>Results</title> <p>Among the 1126 included patients, 148 had an ESUS (ESUS+ group) and 978 had strokes of known origin (ESUS– group). A LASP was present in 176 patients, including 32 patients (21.6% of LASPs) in the ESUS+ group and 144 patients (14.7% of LASPs) in the ESUS– group. In multivariate analysis, LASP was independently associated with ESUS (<italic>P</italic> = 0,019). 61.9% of LASPs that we found were not mentioned in reports from the original TEE operators.</p></sec> <sec id="j_jtim-2021-0055_s_010"> <title style='display:none'>Conclusion</title> <p>This study demonstrated that LASPs were more prevalent in patients with ESUS than in patients with strokes of known origin. Our results gave rise to the question of whether anticoagulation would be appropriate for some patients with ESUS. New large-scale, prospective studies should be conducted to address this issue. Additionally, considering the low rate of LASP descriptions, we concluded that the awareness of operators should be raised to improve their success in identifying LASPs.</p> </sec> </abstract>ARTICLE2022-04-06T00:00:00.000+00:00Basic pancreatic lesions: Radiologic-pathologic correlationhttps://sciendo.com/article/10.2478/jtim-2022-0003<abstract> <title style='display:none'>Abstract</title> <p>The basic pancreatic lesions include location, size, shape, number, capsule, calcification/calculi, hemorrhage, cystic degeneration, fibrosis, pancreatic duct alterations, and microvessel. One or more basic lesions form a kind of pancreatic disease. As recognizing the characteristic imaging features of pancreatic basic lesions and their relationships with pathology aids in differentiating the variety of pancreatic diseases. The purpose of this study is to review the pathological and imaging features of the basic pancreatic lesions.</p></abstract>ARTICLE2022-04-02T00:00:00.000+00:00The first patient with sporadic Huntington’s disease due to a (CAG)n expansion in Chinahttps://sciendo.com/article/10.2478/jtim-2022-0006ARTICLE2022-04-02T00:00:00.000+00:00Inflammatory factors driving atherosclerotic plaque progression new insightshttps://sciendo.com/article/10.2478/jtim-2022-0012<abstract> <title style='display:none'>Abstract</title> <p>Coronary atherosclerosis is a chronic inflammatory disease that can lead to varying degrees of blood flow obstruction and a common pathophysiological basis of cardiovascular disease. Inflammatory factors run through the whole process of atherosclerotic lesions. Macrophages, T cells, and neutrophils play important roles in the process of atherosclerotic inflammation. Considering the evolutionary characteristics, atherosclerosis can be divided into different stages as early atherosclerotic plaque, plaque formation stage, and plaque rupture stage. In this paper, the changes in inflammatory cells at different stages of lesions and their related mechanisms are discussed, which can provide new insights from a clinical to bench perspective for atherosclerosis me chanism.</p></abstract>ARTICLE2022-04-02T00:00:00.000+00:00Advances in the application of regenerative medicine in prevention of post-endoscopic submucosal dissection for esophageal stenosishttps://sciendo.com/article/10.2478/jtim-2022-0011<abstract> <title style='display:none'>Abstract</title> <p>Endoscopic submucosal dissection (ESD) is a curative treatment for superficial esophageal cancer with distinct advantages. However, esophageal stenosis after ESD remains a tough problem, especially after large circumferential proportion of esophageal mucosa is removed, which limits the wide use of ESD, especially in circumferential lesions. In this scenario, preventive procedures are highly recommended against post-ESD esophageal stenosis. However, the efficacy and safety of traditional prophylactic methods (steroids, metal and biodegradable stents, balloon dilation, radial incision, <italic>etc</italic>.) are not satisfactory and novel strategies need to be developed. Regenerative medicine has been showing enormous potential in the reconstruction of organs including the esophagus. In this review, we aimed to describe the current status of regenerative medicine in prevention of post-ESD esophageal stenosis. Cell injection, cell sheet transplantation, and extracellular matrix implantation have been proved effective. However, numerous obstacles still exist and further studies are necessary.</p></abstract>ARTICLE2022-04-02T00:00:00.000+00:00Dysregulation of miR-144-5p/RNF187 axis contributes to the progression of colorectal cancerhttps://sciendo.com/article/10.2478/jtim-2021-0043<abstract> <title style='display:none'>Abstract</title> <sec id="j_jtim-2021-0043_s_005"> <title style='display:none'>Background and Objectives</title> <p>RING finger protein 187 (RNF187) belongs to RING domain-containing E3 ligases family, which was recently reported to be involved in oncogenesis and development of several cancers. This research aims to clarify the role of RNF187 in colorectal cancer (CRC) development.</p> </sec> <sec id="j_jtim-2021-0043_s_006"> <title style='display:none'>Methods</title> <p>The expression of RNF187 and miR-144-4p were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The levels of RNF187 protein were assessed by western blot analysis. Cell Counting Kit-8 (CCK8) assay, clonogenic assay, cell scratch test and transwell assay were used to determine the proliferation, migration and invasion of CRC cells in vitro. The binding of miR-144-5p and RNF197 mRNA was validated by luciferase reporter assays. Tumor-bearing nude mice were used to determine CRC cells growth in vivo.</p></sec> <sec id="j_jtim-2021-0043_s_007"> <title style='display:none'>Results</title> <p>RNF187 expression significantly increased in CRC specimens and cell lines compared to normal colon tissues and normal colonic mucosa cell line, respectively. Upregulation of RNF187 expression was inversely correlated to poor prognosis in CRC patients. In addition, knockdown of RNF187 expression inhibited the proliferation, migration, and invasion but promoted the apoptosis of CRC lines Caco-2 and SW480 cells. Further studies validated that RNF187 was the direct target of miR-144-5p. The expression of miR-144-5p was downregulated in CRC tissues, which was negatively correlated to the expression of RNF187. Restoration of miR-144-5p significantly inhibited the progression of CRC cells and its anti-tumor effects could be abrogated by overexpression of RNF187.</p></sec> <sec id="j_jtim-2021-0043_s_008"> <title style='display:none'>Conclusion</title> <p>Our findings demonstrate the deregulation of miR-144-5p/ RNF187 axis in CRC, as well as its role in regulation of the tumor progression, thus providing a novel therapeutic strategy for CRC treatment.</p> </sec> </abstract>ARTICLE2022-03-26T00:00:00.000+00:00Hydrogel: A promising new technique for treating Alzheimer’s diseasehttps://sciendo.com/article/10.2478/jtim-2022-0008ARTICLE2022-03-26T00:00:00.000+00:00Research progress on the role of probiotics in acute liver failurehttps://sciendo.com/article/10.2478/jtim-2021-0052ARTICLE2022-03-10T00:00:00.000+00:00Chronic stress-induced immune dysregulation in breast cancer: Implications of psychosocial factorshttps://sciendo.com/article/10.2478/jtim-2021-0050<abstract> <title style='display:none'>Abstract</title> <p>Chronic stress refers to continuous emotional changes and psychological pressure that individuals experience when they are unable to adjust and stabilize the internal environment over an extended period. It can increase the pressure on endocrine mediators and cytokines in the circulation, as well as tissues throughout the hypothalamic-pituitary-adrenaline (HPA) axis and sympathetic nervous system (SNS); thus, evolving the internal environment of the tumor. This review assesses several key issues, involving psychosocial factors, and integrates clinical, cellular, and molecular studies—as well as the latest research progress—to provide a mechanistic understanding regarding breast oncopsychology. We propose that chronic stress contributes to large individual differences in the prognosis of breast cancer survivors because they change the basic physiological processes of the endocrine and immune systems, which in turn regulate tumor growth. The study of psychological and physiological reactions of breast cancer patients suggests a new idea for psychological intervention and clinical treatment for breast cancer patients.</p></abstract>ARTICLE2022-03-05T00:00:00.000+00:00The long and the short of current nanomedicines for treating Alzheimer's diseasehttps://sciendo.com/article/10.2478/jtim-2021-0054ARTICLE2022-03-05T00:00:00.000+00:00Retinal examination modalities in the early detection of Alzheimer's disease: Seeing brain through the eyehttps://sciendo.com/article/10.2478/jtim-2021-0053ARTICLE2022-03-05T00:00:00.000+00:00en-us-1